Voriconazole Powder

CAS:137234-62-9
MF:C16H14F3N5O
MW:349.31
Package: 100g/bag;500g/bag;1kg/bag
Origin: China
Supply Ability: 100kg per month
Sample Available: Yes
Shelf Life: Two years
Payment: T/T, LC or DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Third Party Test: available
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Product Introduction

What is Voriconazole powder?

Voriconazole powder is a dihydrofurano triazoline analogue. it's a white to slightly unheroic crystalline powder. it's answerable in water and utmost organic detergents. Its chemical name is( 2R, 3S)- 2-( 2,4- difluorophenyl)- 3-( 5- fluoropyrimidin-4-yl) propanoic acid, its molecular formula is C16H14F3N3O4, its molecular weight is349.29 g/ spook, and its CAS number is 137234-62-9.

As a triazole antifungal medicine raw material, it inhibits the conformation of the trimer of incentive cell wall conflation by targeting the inside of the fungal cell membrane, causing pores in the cell membrane and leading to cell death.

Pfizer began clinical trials and submitted an operation to theU.S. Food and Drug Administration in 2000.

In 2002, the FDA approved it for the treatment of invasive aspergillosis and other invasive fungal infections.

In 2003, the European Medicines Agency( EMEA) also approved its use.

In 2006, it was listed as an essential medicine in the List of Essential Medicines by the World Health Organization. It came one of the most important, safe and effective medicines.

Since also, it has been extensively used to treat invasive aspergillosis and other invasive fungal infections, and has gradationally come the preferred medicine for antifungal remedy. Due to its broad- diapason exertion, effectiveness, and good oral bioavailability, its position in the antifungal medicine request has come decreasingly stable.

Basic Information

Product name

Voriconazole

Chemical name

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl) propanoic acid

CAS

137234-62-9

MF

C16H14F3N5O

MW

349.31

EINECS

629-701-5

MDL No.

MFCD00905717

Purity

99%

Stability

stable when stored under appropriate conditions.

solubility

DMSO >20mg/mL

Application

used for research.

Packing

As per your request

Storage

Room temp.

Structural formula

       137234-62-9.webp        


Quality standard

Items

Specification

Results

Appearance

White to almost white crystalline powder

white crystalline powder

Solubility

Freely soluble in acetone and in methylene chloride, soluble in methanol and in chloroform, practically insoluble in water

Conforms

Melting point

129℃~134℃

129.0℃~130.8℃

Specific rotation

(1% solution in methanol )

-57.0°~-61.0°

-58.86°

Identification

A: UV

Conforms


B: HPLC

Conforms

Related substances

(by HPLC)

Individual impurity NMT 0.5%

0.03%


Total impurities NMT 1.0%

0.07%

Optical isomer

MNT 0.5%

ND

Residual solvents(by HPLC)

Ethyl acetate NMT0.5%

ND


Chloroform NMT0.006%

ND


Methanol NMT0.3%

ND


Isopropanol NMT0.1%

ND

Loss on drying(in vacuum at 80℃ till constant weight)

NMT 0.5%

0.03%

Residue on ignition

NMT 0.1%

0.02%

Heavy metals

NMT 20ppm

Conforms

Chlorides

NMT 0.02%

Conforms

Sulfates

NMT 0.02%

Conforms

Fluorine

14.7%~17.9%

15.2%

Assay(on dried basis)

NLT 98.5%

100.1%

Conclusion

The test results conforms with the above specifications


Stability

Voriconazole powder stability is affected by numerous factors similar as temperature, moisture, light exposure, oxygen, pH value, etc. Under applicable conditions, it generally has good stability and can be stored for a long time.

According to pharmacopoeia regulations, it should be stored in a dry, dark and coolplace. The temperature shouldn't exceed 25 ℃ and the relative moisture shouldn't exceed 60. For powder, sealed holders should be used for storehouse to avoid humidity immersion and impurity.

In addition, to ensure its stability, the following points need to be noted

Avoid dragged exposure to light, as UV and visible light can reduce its stability.

Pay attention to precluding it from being defiled by oxidation or other adulterants in the air.

When preparing medicines, high-quality raw accouterments should be named, and applicable styles should be taken to ensure their quality and chastity.

In summary, when storing and using it, applicable operation procedures and norms must be precisely followed to ensure its optimal stability and efficacity.

Dragged exposure to strong light or high temperature and moisture surroundings should be avoided to help loss of quality.


Storage

Antifungal Voriconazole is generally stored in sealed plastic or glass holders. The ensuing points need to be noted when storing it

Avoid humidity immersion it's prone to humidity immersion, which can affect the quality of the medicine, so it should be placed in a dry place.

Avoid impurity it's prone to oxidation or impurity by other adulterants, so communicate with air or other adulterants should be avoided.

Avoid vibration during transportation, handling, or use, it should be defended from strong climate or impacts.

When storing and using it, strict compliance with operation procedures and norms is necessary to insure the quality and safety of the medicine. When using it, standard procedures should be followed for analysis or processing to insure its optimal effect.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

Item

Quantity

ETA time

Shipping Method

By Courier

≤50kg

7-15days

Fedex, DHL,UPS,TNT,EMS ect.

Fast and convenient

By Air

50kg~200kg

3-5days

Fast and cheap

By Sea

Large quantity

20-35days

Cheapest way

Payment Term

payment.webp

Why Choose Xi'an Yihui?

Customer feedback

Customer Comments.webp

Xi'an Yihui certificates

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Xi'an Yihui Factory & Warehouse

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, Xi'an Yihui company as a professional Voriconazole powder manufacturer, has strong technical strength and advanced production equipment, and is committed to providing customers with high -quality, efficient and reliable drug raw materials. if you need it, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937

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