What is 99% Latanoprost?

99% Latanoprost is a prostaglandin analog that belongs to the family of prostaglandins. Prostaglandins partake a common point of having substituents on the cyclopentane ring. PGF2α prostaglandins and prostaglandin analogs generally have two hydroxyl groups on the cyclopentane ring, which are in a cis configuration relative to each other. They also have two side chains in a trans configuration to each other, and each side chain contains a double bond. Prostaglandin analogs of PGF2α can have different figures of double bonds on their side chains and different substituents along the side chain. also, in some PGF2α analogs, the carboxylic acid group on the side chain can be esterified. It is a PGF2α analog with a logged side chain, and the carboxylic acid group is esterified. This emulsion is clinically used to reduce elevated intraocular pressure in cases with open- angle glaucoma and optical hypertension.

Basic Information

Product Name: Latanoprost

CAS No.: 130209-82-4

MF:C26H40O5

MW:432.59

EINECS:634-172-9

MDL No.:MFCD00216074

Boiling point:583.8±50.0 °C(Predicted)

Density 1.093±0.06 g/cm3(Predicted)

storage : Preserve at 2℃~8℃ in airtight and light resistant containers

solubility DMSO: freely soluble

Appearance：light yellow oil

Stability: Stable for 2 years

Structural formula:

Quality standard

Function & Application

99% Latanoprost is a synthetic drug, which is a prostaglandin F2α analogue. The following are the functions and applications:

Reduce intraocular pressure it's substantially used to treat glaucoma and high intraocular pressure. It lowers intraocular pressure by adding waterless exodus and reducing waterless products, therefore relieving symptoms in glaucoma cases.

Promote relaxation of the ciliary muscle it can stimulate relaxation of the ciliary muscle, which dilates the pupil. thus, it's generally used as an adjuvant medicine before ophthalmic surgery to help give better visual field and operating conditions.

Treat eyelid ptosis it can also be used to treat eyelid ptosis by promoting compression of the eyelid muscles, and perfecting drooping of the eyelids.

Other operations it's also used to treat other eye conditions similar as keratitis and corneal ulcers.

It should be noted that It is a tradition medicine and should be used under the guidance of a croaker. During use, some side goods may do, similar as eye vexation, eye greenishness, and blurred vision. However, immediate medical attention should be sought, If serious adverse responses do.

Preparation

Weigh 0.504g of PGX-17 (0.65mmol) and add it to a 50ml round-bottom flask equipped with a magnetic stirring bar. Add acetone (6.5ml) to the flask, and store the resulting colorless solution at room temperature under a gentle stream of argon gas. Prepare an aqueous solution (0.9mL) of pyridine tosylate (Aldrich, 13mg), and add it to the reaction solution. The resulting white turbid suspension is stored at room temperature under a stream of argon gas. After approximately 20 minutes, the mixture becomes transparent, forming a colorless solution. After 3 hours, TLC analysis shows complete conversion to the desired product. Stop stirring, and remove the acetone from the reaction mixture through vacuum concentration. Distribute the residue between ethyl acetate( 10mL) and impregnated sodium chloride result( 15mL). Separate the organic phase, and prize the waterless phase with fresh ethyl acetate( 2 ×7.5 mL). Wash the combined organic excerpts with impregnated sodium chloride result( 2 × 10mL), dry with sodium sulfate(0.5 g), and dematerialize under reduced pressure until dry. Obtain a colorless oily crude product. Purify the crude product by rapid column chromatography. Use silica gel 60 (6g) and a mixture of hexane/ethyl acetate (1:1) as the eluent for the rapid column. Dissolve the crude product (taking out 7mg as a reserved sample) in the eluent (2ml) and load it onto the column. Subsequently, eluting with a mixture of hexane/ethyl acetate as described below, combine the fractions containing the pure product, and evaporate under reduced pressure until dry. Obtain a colorless, viscous oily pure product, and dry it under high vacuum (0.01kPa) to constant weight (0.251g, 89.3% yield).

Production method

Compound (Ⅰ) is dissolved in toluene and cooled to 18℃. N, N'-Dicyclohexylcarbodiimide (DCC), and phosphoric acid are added, followed by the addition of (4-phenyl-3-t-butyloxycarbonyloxy) triphenylstannane iodide. The reaction results in the formation of a compound (Ⅱ), which is then converted into the final product through six additional steps of reaction.

Molecular structure

Latanoprost contains a pentene ring with α- and ω-carbon chains. The ester moiety at the end of the α-carbon chain facilitates corneal penetration. In the corneal stroma, Latanoprost is hydrolyzed into the free acid form, which serves as the active moiety. It binds to the FP receptor and contains a hydroxy group at C15. At the end of the chain, there is a short ω-chain and a phenyl ring, which are important for its pharmacological effects.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization:Customized logo;Customized packaging;Graphic customization

Shipping:

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

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In conclusion

In summary, as a professional 99% Latanoprost manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

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