What is Aprotinin powder?

It is a serine protease asset uprooted from beast apkins. Trypsin, plasmin, thrombin, kallikrein, and other tube proteases, as well as clotting factors, can all be inhibited by it. In addition to precluding the fibrinolytic system from being actuated, Aprotinin powder also prevents platelet aggregation. also, it decreases the consumption of clotting factors by blocking the natural coagulation pathway. In further than 50 of major procedures, it significantly reduces surgical bleeding and constantly eliminates the need for blood transfusions. A white to slightly unheroic powder makes up the product. It's undoable in ethanol, acetone, or ether but answerable in physiological saline or water.

It is a protease inhibitor with a development history dating back to the 1950s. Here is a brief overview of the development history of it:

1952: The earliest sample of it was isolated from bovine lungs by Swedish researchers Karl Kallikrein and Herman Kalz. They named this protease inhibitor Trasylol.

1963:Trasylol was successfully used in cardiac surgery, getting the first protease asset used for surgical hemostasis.

1993:Following blessing from theU.S. Food and Drug Administration( FDA), Bayer began dealing Trasylol in theU.S. request.

2006:It came extensively used encyclopedically as a surgical hemostatic agent, particularly in cardiac surgery.

2008: A clinical trial called the BART study found that the use of Trasylol may increase the mortality rate compared to other hemostatic drugs. As a response, Bayer decided to suspend global sales of Trasylol and conduct further research.

2011:After reassessment and exploration, the FDA agreed to renew the use of Trasylol with stricter operation restrictions and warnings.

still, due to safety enterprises, the use of Aprotinin powder has been confined in requests worldwide and has gradationally been replaced by other hemostatic medicines. presently, It is still used in specific situations in certain countries and regions, but its compass of use has significantly dropped.

Basic Information

Product name: Aprotinin

Other name: APT;TRYPSIN INHIBITOR, PANCREAS TYPE;TRYPSIN INHIBITOR (BASIC);TRYPSIN INHIBITOR, BOVINE LUNG

CAS:9087-70-1

MF: C284H432N84O78R2S7

MW:6495.43988

EINECS:232-994-9

MDL No.:MFCD00130541

Activity（anhydrous basis）：≥3.0EPU/mg

storage temp. 2-8°C, Preserve in tight, light-resistant containers.

Stability: Stable

Structural formula:

Quality standard

Target

In vitro studies

Pure Aprotinin is a small molecule inhibitor of fibrinolysis that inhibits trypsin and related proteinases. In cell biology, it is used as a protease inhibitor to prevent protein degradation during tissue homogenization and cell lysis. It inhibits fibrinolytic activity in a dose-dependent manner and prolongs clotting time. In vitro, it is an effective inhibitor of the intrinsic coagulation pathway.

In vivo studies

It inhibits clot lysis in vitro, prolongs tail bleeding time in rats, and prolongs clotting time in mortal tube. In a rat venous shunt model,It reduces thrombus weight.

Production method

Fresh or frozen bovine lung is diced and uprooted with water, followed by ammonium sulfate rush. The precipitate is treated with trichloroacetic acid to remove contaminations, and also subordinated to multiple way including dialysis, desalting, and rush to gain aprotinin.Function & Application

Function

Aprotinin's main function is to act as a small patch asset of fibrinolysis, inhibiting pancreatic proteases and related protein hydrolyzing enzymes. In addition to this, It also has the following functions

• Reduce surgical bleeding:it's an effective hemostatic agent that can reduce blood loss during surgery and ameliorate surgical success rates.

• Protect organs from ischemia-reperfusion injury: it can cover important organs similar as the heart, lungs, and liver from ischemia- reperfusion injury by inhibiting seditious responses and platelet activation.

• Anti-inflammatory effects:it can palliate seditious responses and reduce the product of seditious intercessors, therefore furnishing a remedial effect for seditious conditions.

• Treatment of pancreatitis: it can lower the mortality rate in patients with acute pancreatitis and alleviate symptoms and complications associated with the condition.

Application

The main applications of it include:

Hemostasis during major surgeries: it is commonly used as a hemostatic agent, particularly in large surgeries such as cardiac and pulmonary procedures.

Organ transplantation surgeries such as liver and heart transplants: it can protect organs from ischemia-reperfusion injury during transplantation.

Treatment of acute pancreatitis: it can lower the mortality rate in patients with acute pancreatitis.

Treatment of inflammatory diseases: it has a certain therapeutic effect on inflammatory diseases.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

Payment Term

Why Choose Xi'an Yihui?

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, as a professional Aprotinin powder manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

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