Acitretin API

Product name: Acitretin
CAS No.: 55079-83-9
MOQ: 1kg
Assay: 99%
Brand: YIHUI
Packing: 1kg/bag; 5kg/bag
Supply Ability: 300kg per month
Used: medicine grade; or research
Delivery Time:in stock
Shelf Life: Two years
Payment: T/T, LC or DA
Can’t sell to individuals
  • Fast Delievery
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Product Introduction

What is Acitretin API?

Acitretin API, is a drug made from vitamin A, also known as all-trans retinoic acid or betarretin A. It controls how many skin cells proliferate and differentiate while also affecting how the stratum corneum develops. It improves disorders like keratosis, lessens acne, and controls skin pigmentation by attaching to the vitamin A acid receptor in the nucleus of cells and changing gene transcription and protein expression. With a molecular weight of 326.43 g/mol and a chemical formula of C21H26O3, It often takes the form of a yellowish crystal or crystalline powder. It has the CAS number 55079-83-9. Hexane can be used to solidify it, and its melting point is 228 – 230 °C. The LD50 by intraperitoneal injection ranges from> 4000 mg/ kg( 1 day) to 700 mg/ kg( 10 days and 20 days), according to exploration on acute toxin in mice. The active metabolite of tretinoin is acitretin, a synthetic sweet counterpart of vitamin A. In addition to other skin conditions, it's used to treat severe psoriasis and keratosis.

Basic Information 

Product name: Acitretin





MDL No.:MFCD00866632

Melting point:228-230°C

Boiling point:404.46°C (rough estimate)

Density 1.1348 (rough estimate)

refractive index 1.4700 (estimate)

storage temp. -20°C

Stability: Stable

Structural formula:


Quality standard 





Yellow or greenish-yellow crystalline powder

yellow crystalline powder


Meet the requirements

Meet the requirements


Practically insoluble in water, sparingly soluble in tetrahydrofuran, slightly soluble in acetone and alcohol, very slightly soluble in cyclohexane


Residual solvent

( as Ethyl Acetate)



Loss on drying



Sulphated ash



Heavy metals





Not examined

Particle size

Tapped density

Loose density





Related substances

Individual impurity:≤0.3%


Total impuritites: ≤1.0%


Assay (On dried basis)



Conclusion: It complies with the EP

Packing storage: in tight containers. The dry powder at controlled room temperature.

Function & Application

Acitretin API is an oral medication belonging to the retinoid class of drugs. It is primarily used to treat various skin conditions, particularly severe psoriasis (severe plaque psoriasis), keratinization disorders, and palmoplantar keratoderma.

The following is a list of it application and functions:

  • Psoriasis treatment: it reduces the itching, scaling, red spots, and joint pain associated with psoriasis. It controls cellular division and proliferation, which lessens excessive keratinization and inflammatory reaction and lessens the severity of psoriasis.

  • Treatment of keratinization disorders: it can be used to treat loricrin keratoderma and non-epidermolytic palmoplantar keratoderma. The symptoms and look of the skin are improved by reducing excessive skin keratinization.

  • Treatment of palmoplantar keratoderma: it can treat palmoplantar keratoderma by reducing the thickness and level of keratinization in the palms and soles, alleviating symptoms such pain, fissures, and increasing keratinization.

It may cause side effects during therapy, such as dry mouth, cheilitis, eye symptoms, and altered liver function, thus it's crucial to be aware of this. As a result, it should be used under the supervision of a physician, with ongoing evaluation of its efficacy and safety. it is also not advised for use by women who are expecting or nursing because it could harm the fetus or newborns.

Adverse reactions

Dry lips, cheilitis, angular stomatitis, dry or irritated oral mucosa, and transitional epithelium are signs of high vitamin A levels. Intolerance to contact lenses, keratitis, corneal ulceration, and conjunctivitis. signs of intestinal inflammation. a thirst and a sweat. hair loss that is reversible. skin that is thinner and scaly. Paronychia, unusual nail growth, granuloma, and occasional skeletal, joint, and muscular pain. decreased high-density lipoprotein, increased triglycerides and cholesterol, elevated transaminases and alkaline phosphatase. Increased intracranial pressure symptoms include headache, blurred vision, excessive calcification, extraosseous calcification, osteoporosis, and early epiphyseal plate closure.

Production method

4-methoxy-2,3,6-trimethylbenzaldehyde (Ⅰ) and ethyl formate react in phosphoric acid-containing ethanol to yield compound (Ⅱ) with a yield of 84%. Then, it reacts with (Ⅲ) in ethyl acetate containing zinc chloride to yield a mixture of 6:4 (E)-(Ⅳ) and (Z)-(Ⅳ), with a total yield of 83%. Acid elimination gives 27% of (E,E)-(V) and 21% of (Z,E)-(V). (E,E)-(V) reacts with acetone in a methanol-water solution to yield 25% of compound (Ⅵ). It reacts with ethoxyethynylmagnesium bromide Grignard reagent in ether to yield compound (Ⅶ) with a yield of 48%. Finally, hydrolysis yields a 91% product.

Stability & storage

It is a derivative of vitamin A acid. Its stability and storage conditions are as follows:

Stability: It can be relatively stable for a long time when stored in dry, light-protected, and sealed conditions. However, it is sensitive to light and can easily degrade and lose effectiveness when exposed to light. Additionally, It is also sensitive to high temperatures and oxygen, which may reduce its stability.

Storage conditions: To ensure the stability of it, the following storage conditions are recommended:

  • Temperature: Store it at room temperature (15°C - 30°C).

  • Humidity: Maintain a relatively low humidity level and avoid humid environments.

  • Light: Place it in light-protected containers to prevent direct exposure to light.

  • Packaging: Use sealed containers or packaging materials to ensure proper sealing.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization:Customized logo;Customized packaging;Graphic customization




ETA time

Shipping Method

By Courier



Fedex, DHL,UPS,TNT,EMS ect.

Fast and convenient

By Air



Fast and cheap

By Sea

Large quantity


Cheapest way

Payment Term


Why Choose Xi'an Yihui?

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, as a professional Acitretin API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

our contact information:


Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937

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