What is Pimobendan API?

Pimobendan CASNo.74150-27-9 is a drug used to treat canine heart complaints and has positive inotropic and vasodilatory- dihydro- 6-( 2-( 4- methoxyphenyl)- 1H- benzimidazole-5-yl) is its chemical name.It's known as 5- methyl- 3( 2H)- pyridazine and is a white, liquid powder. In the late 1990s, Boehringer Ingelheim first created the drug, which was also released into the request. It has grown in fashionability as one of the top treatments for canine habitual heart failure.

Pimobendan API, a binary-action drug, increases cardiac muscle cells' perceptivity to calcium ions, enhancing myocardial contractility and the heart's capability to pump blood more effectively. also, it lessens the strain on the heart by enlarging venous blood highways by boosting the expression of the vascular endothelial growth factor endothelin- 1. it has decreasingly become the first-line remedy for canine habitual heart failure as time goes on. Dogs with cardiac disorders like mitral valve disease and aortic valve disease, especially those in the early or severe stages of canine heart disease, have frequently received this treatment.

Basic Information

Product name: Pimobendan

Other name: 3(2H)-Pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- (9CI);dl-Pimobendan

CAS:74150-27-9

MF: C19H18N4O2

MW:334.37

EINECS:640-420-7

MDL No.:MFCD00761648

Melting point: approximate 243℃ (dec.)

Density 1.36

storage temp. 2-8°C

Stability: Stable

Structural formula:

Quality standard

In vitro studies

It widely inhibits PADI insulated from guinea gormandizer myocardium, with an IC50 of0.32 µM. It shows no significant inhibition of PDEI and PDEII, with IC50 values lesser than 30 μM. it inhibits cAMP- PDEIII exertion with an IC50 of2.4 μM and exhibits positive inotropic goods on insulated guinea gormandizer papillary muscles, with an EC50 of6.0 μM. When applied to mortal atrial cells at an attention of 100 μM, it significantly enhances the L-type calcium current( ICa( L)) by 250.4, with an EC50 of 1.13 μM. In rabbit atrial cells, it increases ICa( L) by 67.4, but to a lower extent compared to its effect on mortal atrial cells.

In vivo studies

It exhibits salutary goods on EMC contagion- convinced myocarditis in mice, particularly in terms of extending lifetime. Treatment with it significantly improves the overall survival rate, adding it from33.6( control group) to53.3(0.1 mg/ kg) or66.7( 1 mg/ kg). When administered at a cure of 1 mg/ kg, it significantly reduces myocardial cell infiltration compared to the control group. It also decreases the situations of excrescence necrosis factor( TNF)- α and interleukin( IL)- 1β in the cardiac depression, without affecting cardiac jitters, heart weight, or body weight. It inhibits the expression of the iNOS gene in the heart, leading to a drop in nitric oxide( NO) product within the heart.

Function & Application

It is a drug that acts on the cardiovascular system, primarily by enhancing myocardial contractility and dilating coronary highways. It's extensively used for the treatment of heart failure and conditions similar as restrictive pericarditis. it enhances myocardial contractility by widely inhibiting the exertion of PDEIII enzyme and promotes coronary roadway dilation by acting on L- type calcium channels. also, this drug also affects the cardiac nervous system, regulating the balance between the sympathetic and parasympathetic jitters, thereby perfecting conditions similar as cardiac arrhythmias. In summary, it's an effective cardiovascular drug used to treat colorful cardiovascular conditions.

Stability and storage

Pimobendan API has good stability, but it still requires appropriate storage conditions to maintain its efficacy and quality. Here are the storage guidelines for it:

Temperature it should be stored in a dry and cool place at room temperature( 15- 30 degrees Celsius). Avoid exposure to exorbitantly high or low temperatures, as it may affect its stability.

Light It's judicious to avoid direct exposure to sun or strong light, as light can reduce its stability. Using a sealed vessel or packaging can cover the drug from light exposure.

moisture Avoid storing it in sticky or wettish surroundings, as moisture can lead to corruption or loss of effectiveness. It's recommended to store the drug in a dry place and insure proper sealing to help humidity.

Packaging it's generally supplied in sealed tablets or capsules. Keep the packaging complete and don't open it until ready for use to help the drug from being exposed to air or humidity.

Please follow the drug's instructions for use and consult with a druggist or healthcare professional to ensure proper storehouse and operation of Pimobendan. However, please seek advice from a medical professional, If you have any questions regarding the storehouse or operation.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization:Customized logo;Customized packaging;Graphic customization

Shipping:

Payment Term

Why Choose Xi'an Yihui?

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition, and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, as a professional Pimobendan API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us at any time. we will reply to you ASAP.

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