Exenatide Acetate

CAS: 141732-76-5
Appearance: White to Off-White Powder
Standard: 99%
Application:Drug Peptides & Lab research
Brand: YIHUI
Packing: 1g;10g;100g
Supply Ability: 5000g per month
Shelf Life: Two years
Payment: T/T, LC or DA
Sample: available
Delivery Time: Ready Stock in Local Warehouse,1-3 days
Prompt and Secure Shipment
Origin: China
Shipping: DHL,FedEx,TNT,EMS,By Sea,By Air
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
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Product Introduction

What is Exenatide Acetate?

Exenatide acetate is an engineered simple of exendin-4, a peptide chemical created by the salivary organs of the Gila beast reptile. It is a glucagon-like peptide-1 (GLP-1) receptor agonist, and that implies it ties to and enacts the GLP-1 receptor in the pancreas. This actuation animates the arrival of insulin from beta cells, which assists with bringing down glucose levels.

Basic Information

Product Name: Exenatide acetate

CAS: 141732-76-5




MDL No.:MFCD08704781

form Solid

color White to Off-White

Purity: 98%+

Package: 1g; 5g; 25g

Used: Lab research

Stability: Stable

Structural formula:


Specifications and Parameters:




Physical appearance

White powder


Molecular weight


4186 Da




Single impurity(HPLC)



Amino acid composition

±10% of theoretical


Peptide content (N%)



Water content(Karl Fischer)



Acetate content(HPLC)



Mass Balance



Caution: For laboratory use only, not for human use.

Chemical Composition:

Exenatide Acetate, orchestrated through cutting edge biotechnological processes, is made out of amino acids. The essential arrangement incorporates alanine, glycine, histidine, leucine, proline, and serine, among others. The compound's pharmacological properties and therapeutic efficacy are enhanced by the precise arrangement of its amino acids. It is an engineered simple of exendin-4, a peptide chemical created by the salivary organs of the Gila beast reptile. It is made out of 39 amino acids and has a sub-atomic recipe of C183H288N42O53. The sub-atomic load of exenatide acetic acid derivation is 4186.68.

The chemical structure of exenatide acetate is very similar to that of exendin-4. The only difference is that exenatide acetate has an acetyl group attached to the lysine residue at position 28. This acetyl group makes exenatide acetate more stable and resistant to degradation by enzymes.

Exenatide acetate is a white to off-white powder that is soluble in water. It is typically formulated as a solution for injection.The most well-known symptoms of Exenatide acetate incorporate queasiness, spewing, looseness of the bowels, and stomach torment. These incidental effects are typically gentle and disappear inside half a month. Other possible side effects include fatigue, dizziness, and headache.

Exenatide acetate is a treatment for type 2 diabetes that is both safe and effective. It is regularly utilized in blend with different prescriptions, like metformin or sulfonylureas. It is likewise some of the time used to treat stoutness.

Role and Function:

It is utilized in the treatment of type 2 diabetes since it mirrors the impacts of GLP-1. By restricting to and actuating the GLP-1 receptor, exenatide acetic acid derivation invigorates the arrival of insulin from beta cells, dials back the purging of the stomach, and stifles hunger. These impacts help to bring down glucose levels and further develop glucose control.

Exenatide acetate is commonly utilized in mix with different drugs, like metformin or sulfonylureas. This is on the grounds that exenatide acetic acid derivation isn't compelling in bringing down glucose levels in individuals who produce no insulin.

Additionally, obesity is occasionally treated with exenatide acetate. This is because it can slow down stomach emptying and suppress appetite, both of which can help people lose weight.

Job in the Treatment of Type 2 Diabetes

  • It is a protected and viable treatment for type 2 diabetes. It is regularly utilized in blend with different prescriptions, like metformin or sulfonylureas. Over the course of 24 weeks, it was demonstrated that exenatide acetate reduced HbA1c levels by 1.0 to 1.5 percent.

  • In some cases, it is also used to treat obesity. This is on the grounds that exenatide acetic acid derivation stifles hunger and dials back the discharging of the stomach, which can prompt weight reduction. Over the course of 24 weeks, exenatide acetate was found to reduce body weight by an average of 4.5 kilograms.

  • It is a protected and viable treatment for type 2 diabetes and corpulence. It works by impersonating the impacts of GLP-1, a chemical that is created by the small digestive system

Exenatide acetate is a protected and compelling treatment for type 2 diabetes and stoutness. It works by mimicking the effects of the small intestine-produced hormone GLP-1.

Synthesis Process:

Exenatide acetate is a synthetic analog of exendin-4, a peptide hormone produced by the Gila monster lizard. It is produced using a process called solid-phase peptide synthesis (SPPS).

SPPS is a method for synthesizing peptides by stepwise addition of amino acids to a growing peptide chain. The process is carried out on a solid support, which is typically a resin bead. The amino acids are added to the resin bead in the desired sequence, and each amino acid is coupled to the growing peptide chain using a chemical reaction.

Once the peptide chain is complete, it is cleaved from the resin bead and purified. The purified peptide is then acetylated to form exenatide acetate.

  • Planning of the Gum Globule: The initial step is to set up the tar dot. The pitch dot is regularly made of polystyrene or polyethylene glycol. The gum dab is functionalized with a linker particle, which permits the amino acids to be connected to the gum globule.

  • Coupling of the Main Amino Corrosive: The primary amino corrosive is coupled to the pitch dot utilizing a synthetic response. The amino corrosive is regularly initiated utilizing a coupling reagent, for example, dicyclohexylcarbodiimide (DCC) or 1-hydroxybenzotriazole (HOBt).

  • Coupling of the Excess Amino Acids: The excess amino acids are coupled to the developing peptide chain individually, involving a similar substance response as in sync 2. The request for the amino not entirely settled by the ideal grouping of the peptide.

  • Cleavage of the Peptide from the Tar Globule: When the peptide chain is finished, it is cut from the sap dab utilizing a compound response. The cleavage response is regularly completed utilizing serious areas of strength for a, for example, trifluoroacetic corrosive (TFA).

  • Cleansing of the Peptide: The cleaved peptide is purified using chromatography and crystallization, among other methods.

  • Acetylation of the Peptide: The cleansed peptide is acetylated to frame exenatide acetic acid derivation. The acetylation response is normally done utilizing acidic anhydride or acetyl chloride.

Quality Standards:

Exenatide acetate is a peptide drug that is used to treat type 2 diabetes and obesity. It is a synthetic analog of exendin-4, a hormone that is produced by the Gila monster lizard. Exenatide acetate is manufactured using a process called solid-phase peptide synthesis.

The quality of exenatide acetate is critical to its safety and efficacy. The following are some of the product quality standards that are applied to exenatide acetate:

  • Identity: The character of exenatide acetate is affirmed utilizing various logical methods, like superior execution fluid chromatography (HPLC) and mass spectrometry.

  • Purity: The immaculateness of it still up in the air by estimating how much pollutions in the medication item. The pollutants are commonly evaluated utilizing HPLC.

  • Potency: It's ability to bind to and activate the GLP-1 receptor is used to determine its potency. The strength is ordinarily communicated in units of IU/mg.

  • Sterility: It is a sterile medication item.

Yihui, as a leading manufacturer, adheres to stringent quality standards to ensure the excellence of Exenatide Acetate. Our production processes align with international benchmarks, and our facilities boast certifications including ISO, Kosher, Halal. These certifications underscore our commitment to delivering a product that meets the highest industry standards and regulatory requirements.

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Application Fields in Various Industries :

Exenatide acetate is a GLP-1 receptor agonist that is utilized to treat type 2 diabetes and weight. It is an engineered simple of exendin-4, a chemical that is created by the Gila beast reptile. It is normally utilized in blend with different drugs, like metformin or sulfonylureas.

Notwithstanding its utilization in the drug business, it has likewise been investigated for use in different ventures, including:

  • Veterinarian practice: Diabetes in dogs and cats can be effectively treated with exenatide acetate. It is regularly utilized in mix with different drugs, like insulin.

  • Cosmetics: The skin has been shown to benefit from the anti-aging effects of exenatide acetate. It is remembered to work by invigorating the development of collagen and elastin, which are two proteins that are liable for the skin's flexibility and solidness.

  • shedding pounds: It has been demonstrated to be compelling in advancing weight reduction in individuals who are overweight or hefty. It is remembered to work by smothering craving and dialing back the discharging of the stomach.

  • Treatment of other metabolic illnesses: It might be powerful in treating other metabolic sicknesses, like non-alcoholic greasy liver illness and polycystic ovary disorder.

  • Neurodegenerative diseases are treated: In animal studies, the neuroprotective effects of exenatide acetate have been demonstrated. It is remembered to work by diminishing aggravation and oxidative pressure.

  • Therapy of disease: It has been displayed to have against cancer impacts in creature studies. It is remembered to work by hindering the development of disease cells and advancing the demise of malignant growth cells.

Packing & Shipping

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1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.


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Rich experience: we have 13 Years of professional experience;

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Contact Us:

Yihui, as a trusted Exenatide Acetate manufacturer, prioritizes quality, adhering to international standards. Our certifications – ISO, Kosher, Halal, and GMP – testify to our unwavering commitment to product excellence. For inquiries or purchases, reach out to us at sales@yihuipharm.com. Join hands with Yihui to experience the pinnacle of quality in Exenatide Acetate production.

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