3-O-Ethyl-L-ascorbic acid

CAS No: 86404-04-8
Appearance: White crystal
Standard: in-house
Supply Ability: 5000kg per month
Shelf Life: Two years
Payment: T/T, LC or DA
Delivery Time: Ready Stock
Origin: China
Shipping: DHL, FedEx, TNT, EMS, By Sea, By Air
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Product Introduction

We supply 3-O-Ethyl-L-ascorbic acid

We're pleased to offer 3-O-Ethyl-L-ascorbic acid, a important and stable form of vitamin C. This innovative component has been specifically designed to enhance collagen conflation and buck up skin tone, making it a largely sought- after addition to a wide range of ornamental phrasings. With its exceptional stability, 3-O-Ethyl Ascorbic Acid offers dependable and harmonious results, icing that your products deliver the stylish possible issues for your guests. So if you are looking for an effective and dependable vitamin C outgrowth to enhance your products, look no further than our vitamin c ethyl ether.


What's 3-O-Ethyl-L-ascorbic acid?

3-O-Ethyl-L-ascorbic acid, also known as vitamin C ethyl ether. Due to its four hydroxyl groups in structure, vitamin C can not be directly absorbed by the skin and is fluently oxidized, leading to abrasion. Its use as a decolorizing agent in cosmetics is limited. The VC ethyl ether attained by 3- hydroxyalkylation is a non discoloring vitamin C outgrowth that doesn't affect its natural exertion, therefore filling the gap in analogous products in the request. Research has shown that it is fluently broken down by enzymes after entering the skin, plying the effect of vitaminC.

it is a veritably useful outgrowth of vitamin C, which isn't only chemically stable and doesn't change color as a vitamin C outgrowth, but also a hydrophilic and amphiphilic substance. This greatly expands its connection in the field of chemical engineering, especially in diurnal chemical operations. 3- O- ethylascorbic acid ether fluently enters the dermis through the stratum corneum, and after entering the body, it's fluently perished by natural enzymes to ply the natural goods of vitamin C.


Basic Information

Product Name: 3-O-Ethyl-L-ascorbic acid

Other name: 3-O-Ascorbyl Ether; 3-O-Ethyl Ascorbic Acid; Ethyl Ascorbic Acid; Vitamin C ethyl ether





MDL No.:MFCD09261382

Structural formula:


Purity: 99%+

Origin: China

Application: Skin Whitening

Melting point: 112.0 to 116.0℃

Boiling point: 551.5 ± 50.0 ℃ (Predicted)

Density: 1.46 ± 0.1g/cm3 (Predicted)

Solubility: methanol (slightly soluble), water (slightly soluble


Technical Specification:





White crystal

White crystal

Melting point






Residue on ignition



Loss on drying



Heavy metal



Free vitamin C









Bacterria total

≤100 cfu/g

≤100 cfu/g

Mould and yeast total

≤50 cfu/g

≤50 cfu/g

Staphylococcus aureus



Psedomonas aeruginosa



Conclusion:Complies with the requirements of enterprise

Package: 1kg;25kg

Storage conditions: Keep in dark place, Inert atmosphere,2-8°C


What is the Main function of 3-O-Ethyl-L-ascorbic acid?

l. After entering the dermis, VC ethyl ether directly participates in the synthesis of collagen to repair skin cell activity, increasing collagen and making the skin full and elastic, making the skin delicate and smooth.

2. Inhibiting tyrosinase activity, inhibiting melanin formation, reducing melanin to colorless, and efficiently whitening the skin.

3. There is an antioxidant effect in cosmetics, ensuring the utilization of VC. Compared to VC, VC ethyl ether is very stable and does not change color. Truly achieve the effect of whitening and freckle removal.

4. It has an oleophilic and hydrophilic structure, which is easy for the skin to absorb and can reach the dermis directly

5. Strong antibacterial and anti-inflammatory effects, anti inflammation caused by sunlight.

7. Good stability, resistant to light, heat, acid, alkali, salt, and air oxidation

8. The inhibitory effect of vitamin C and its derivatives on tyrosinase


What is the Purpose of 3-O-Ethyl-L-ascorbic acid?

Vitamin C ethyl ether (VC ethyl ether) is an oleophilic and hydrophilic amphoteric vitamin C derivative, which not only retains the redox effect of vitamin C but is also very stable. It is a non discoloring vitamin C derivative, and it is also an oleophilic and hydrophilic amphoteric substance in the chemical book. This not only makes it extremely convenient to use in formulas, but also makes it easy to penetrate the stratum corneum and enter the dermis. After entering the skin, it is easily decomposed by biological enzymes to play the role of vitamin C, thereby improving its bioavailability.


What is the Mechanism of action of 3-O-Ethyl-L-ascorbic acid?

VC ethyl ether reaches the basal layer of melanocytes through the stratum corneum, inhibits tyrosinase activity, inhibits melanin formation, reduces melanin to colorless, and efficiently whitens the skin. And VC ethyl ether can directly participate in the synthesis of collagen and repair skin cell activity after entering the dermis, increasing collagen and making the skin full and elastic, making the skin delicate and smooth. 3-O-ethyl-L-ascorbic acid may be a useful stabilizer for hydroxyacetophenone solutions.


What is the application of 3-O-Ethyl-L-ascorbic acid?

3-O-ethylascorbic acid ether  is a substance that is soluble in both oil and water, allowing formulators to freely add it to the oil or water phase, as well as at high or low temperatures, making it convenient to use. More importantly, this two solubility makes it easier for it to penetrate the stratum corneum and enter the dermis to exert its biological effects, which other vitamin C derivatives do not possess. It can block melanin formation by inhibiting the activity of tyrosinase; Has whitening and freckle removing effects (when added at 2%); Inflammation caused by anti Japanese light has strong antibacterial and anti-inflammatory effects; Simultaneously improving dullness and dullness of the skin, endowing it with radiance and elasticity, repairing skin cell activity, and promoting collagen production.

1. Inhibition of tyrosinase activity by Cu2+acting on it, blocking melanin formation;

2. Very effective whitening and freckle removing effects (when added at 2%);

3. Inflammation caused by anti Japanese light, with strong antibacterial and anti-inflammatory effects;

4. Improve dullness and dullness of the skin, giving it elasticity;

5. Repair skin cell activity and promote collagen production.


Preparation of 3-O-Ethyl-L-ascorbic acid

1) Synthesis of 5,6-O-isopropylidene ascorbic acid: 70g of ascorbic acid, 22g of p-toluenesulfonic acid, and 700ml of acetone were added to a 1.5-liter single necked flask. The reaction was carried out at room temperature (25 ℃) for 8 hours, and a large amount of crystals were generated in the reaction solution. After filtration, the filter cake was washed with acetone and vacuum dried to obtain 80g of 5,6-O-isopropylidene-L ascorbic acid crystals with a yield of 93%. After supplementing with acetone and ascorbic acid, repeating this step of the reaction can cyclically produce 5,6-O-isopropylidene-L ascorbic acid.

2) Synthesis of 3-O-alkyl-5,6-O-isopropylene ascorbic acid: DMSO is used as the solvent, and the molar ratio of bromoethane to ascorbic acid is 0.5/1. Weigh 30 grams of 5,6-O-isopropylidene-L ascorbic acid, dissolve it in 120 milliliters of DMSO, add 7.6 grams of bromoethane and 11.6 grams of sodium bicarbonate, and then react at 70 ℃ for 2 hours. After cooling to room temperature (25 ℃), extract three times with 1000 milliliters of toluene. After washing with water, concentrate and crystallize the extract to obtain 16.2 grams of 3-O-ethyl-5,6-O-isopropylene ascorbic acid, with a yield of 95% calculated by bromoethane. Example 103-O-Ethyl-5,6-O-isopropyleneascorbic acid deprotection:

3) Synthesis of 3-O-ethylascorbic acid: Dissolve 10 grams of 3-O-ethyl-5,6-O-isopropyleneascorbic acid in 100 milliliters of methanol, then add 5 milliliters (volume fraction of 50%) of hydrochloric acid, heat to 60 ℃, and react for 3 hours. After neutralization with sodium bicarbonate and extraction with ethyl acetate, 8.2 grams of 3-O-ethyl ascorbic acid were obtained, with a yield of 98%.


the Usage and dosage of 3-O-Ethyl-L-ascorbic acid

[Application]: Whitening and freckle removing products, anti-aging products, aqua, gel, essence, lotion, skin cream, etc.

[Recommended dosage]: 0.1-2.0%, suitable for whitening and freckle removing products, wrinkle removing and anti-aging products.

[Operation suggestion]: It is best to use under pH 3.0-6.0 conditions for the best whitening and freckle removal effect.


Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.


In conclusion

In summary, as a supplier of 3-O-Ethyl-L-ascorbic acid , Xi'an Yihui has rich production experience and technical knowledge, high-quality products, flexible production capacity, and quality customer service, which can provide better support and service to customers.

if you need vitamin C ethyl ether, pls feel free to contact us any time. we will reply you asap.

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Tel: 0086-29-89695240
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