What is Lenalidomide API?

Lenalidomide API, developed by the American biopharmaceutical company Celgene, is an anti-tumor medicine with a chemical structure analogous to thalidomide. It has multiple conducts including anti-tumor, vulnerable modulation, and anti-angiogenesis goods. It can inhibit the stashing of pro-inflammatory cytokines and increase the stashing of anti-inflammatory cytokines by supplemental blood mononuclear cells. In vitro trials have shown that it can inhibit the proliferation of certain cell lines similar as Namalwa cells. It can inhibit the growth of multiple myeloma cells and MM1S cells. also, it can inhibit the expression of cyclooxygenase- 2( COX- 2) but has no effect on COX- 1. Two multicenter randomized double-eyeless placebo-controlled clinical studies have estimated the safety and efficacity of it in multiple myeloma, and the primary efficacity endpoints were time to complaint progression( TTP). The mid-term analysis showed that the combination remedy group had a significantly better TTP than the dexamethasone monotherapy group. Recent clinical exploration results have shown that It has certain efficacity in the treatment of multiple myeloma, leukemia, metastatic renal cell melanoma, solid excrescences, primary systemic amyloidosis, and systemic bone gist fibrosis associated with myelofibrosis.

It is a new generation outgrowth of thalidomide, but no teratogenic toxin has been set up, and its efficacity is 100 times stronger than thalidomide according to Chemicalbook. According to the results of Phase III clinical trials, It is presently the most effective medicine for the treatment of multiple myeloma, with over half of cases passing a survival extension of further than 3 times after taking the medicine. It's also the only medicine that's effective in treating myelodysplastic runs( MDS), and clinical results have shown that 64 of MDS cases treated with it no longer bear transfusions.

In December 2005, lt was approved by the U.S. Food and Drug Administration( FDA) for the treatment of myelodysplastic runs( MDS).

In March 2006, the FDA approved it, produced by Celgene, for the treatment of multiple myeloma( MM).

On September 23, 2011, the European Medicines Agency( EMA) issued a statement attesting that the benefits of it( trade name Revlimid) in the approved patient population outweigh the pitfalls but also advised croakers about the threat of new malice associated with the medicine. It is used in combination with dexamethasone to treat adult cases with multiple myeloma who have entered at least one previous remedy. Three new studies have shown an increased prevalence of new cancers among cases with recently diagnosed multiple myeloma entering lenalidomide in combination with other curatives.

Basic Information

Product Name: Lenalidomide

CAS:191732-72-6

MF: C13H13N3O3

MW:259.26

EINECS:691-297-1

MDL No.:MFCD18064659

Melting point:265-268℃

Boiling point:614.0±55.0℃(Predicted)

Density 1.460±0.06 g/cm3(Predicted)

storage temp. 2-8°C

solubility Soluble in DMSO (up to 30 mg/ml)

Structural formula:

Quality standard

Biological activity

Lenalidomide is a TNF- αsecretion asset with an IC50 of 13nM in PBMCs. It is a ligand for the ubiquitin E3 ligase cereblon( CRBN), which widely ubiquitinates and degrades two lymphoid recap factors, IKZF1 and IKZF3, through CRBN- CRL4 ubiquitin ligase.It promotes the expression of adhered caspase- 3, inhibits the expression of VEGF, and induces apoptosis.

Mechanism of action

It is an immunomodulatory medicine with multiple mechanisms of action. In in vitro studies, it has been shown to have three main mechanisms 1) directanti-tumor goods, 2) inhibition of angiogenesis, and 3) vulnerable modulation. In vivo, it induces apoptosis of excrescence cells directly or laterally through inhibiting the support of bone gist stromal cells,anti-angiogenic and anti-osteoclast exertion, as well as immunomodulatory exertion. At the molecular position, It has been shown to interact with ubiquitin E3 ligase and target this enzyme for declination of Ikaros recap factors IKZF1 and IKZF3.

Stability and storage

The stability and storage conditions of the lenalidomide API (active pharmaceutical ingredient) are as follows:

Stability it's fairly stable at room temperature but can degrade under the influence of factors similar as light, humidity, and high temperature. It should be defended from exposure to sun as light can beget its declination.

Storage conditions it should be stored in sealed holders, down from light and humidity. The recommended storehouse temperature is 2 °C to 8 °C( cooled) to insure its stability. Under similar conditions, it can be stored for a long time.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization:Customized logo;Customized packaging;Graphic customization

Shipping:

Payment Term

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Rich experience: we have 13 Years of professional experience;

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In conclusion

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