What is Estradiol Benzoate?

Estradiol Benzoate is a type of organic emulsion. its chemical formula C25H28O3. It is an estrogenic medicine that acts in the same way as estradiol. It can stimulate endometrial proliferation, enhance uterine smooth muscle compression, promote mammary gland development and proliferation, explosively inhibit prolactin release at high boluses, offset the goods of androgens, and increase calcium deposit in bones. It is substantially metabolized in the liver and broken down into estradiol. A portion of it binds to coitus hormone- binding globulin( SHBG), while its footloose bit peregrination to target apkins, where it binds to estrogen receptors and produces estrogenic goods through recap and protein conflation. In the liver or feathers, estrogens bind to glucuronic acid or sulfate groups to form water-answerable mariners that are snappily excreted through the feathers.

Basic Information

Product Name:Estradiol benzoate

CAS:50-50-0

MF: C25H28O3

MW:376.5

EINECS:200-043-7

Melting point:191-198 °C(lit.)

storage temp. 2-8°C

Purity:99%

Stability: Stable for 2 years

Application: medicine grade or used for research.

Packing:As per your request

Structural formula:

Quality standard

Function and application

Estradiol Benzoate is a synthetic estrogen compound with the following functions and applications:

Treatment of menopausal pattern Due to the drop in estrogen situations in menopausal women, there can be symptoms similar as reduced bone viscosity and increased threat of cardiovascular conditions. It can replace estrogen and palliate menopausal symptoms.

Prevention of osteoporosis Estrogen is an important controller of calcium immersion in bones, and a insufficiency in estrogen can lead to osteoporosis. Benzyl estradiol, as a synthetic estrogen, helps maintain calcium balance and help osteoporosis.

Promotion of reproductive system health Estrogen plays a pivotal part in the womanish reproductive system by promoting ovarian development, follicle development, and maintaining normal growth and stashing of the uterine endometrium. Benzyl estradiol, as a synthetic estrogen, can replace inadequate estrogen in the body and promote the health of the reproductive system.

Test methods

Content This product is 3- hydroxyestra-( 10)- trien- 17β- ol-3-benzoate, calculated on a dry base, with a content of C25H28O3 ranging from97.0 to103.0.

Appearance This product is a white crystalline powder with no odor.

Solubility Slightly answerable in acetone, slightly answerable in ethanol or vegetable oil painting, undoable in water.

Melting Point The melting point of this product( according to the general rule 0612) is 191- 196 °C.

Specific Gyration Take an applicable quantum of this product, directly weigh it, dissolve it in dioxane, and adulterate it to a result containing 10 mg per 1mL. Measure the specific gyration according to regulations( general rule 0621), which should be between 58 ° and 63 °.

immersion Measure Take an applicable quantum of this product, directly weigh it, dissolve it in anhydrous ethanol, and adulterate it to a result containing 10µg per 1mL. Measure the absorbance at a wavelength of 230nm using ultraviolet-visible spectrophotometry( general rule 0401).

Test

Related substance:Determined by high-performance liquid chromatography (General Rule 0512).

Sample result Take an applicable quantum of the sample, dissolve it in acetonitrile, and adulterate it to a result containing roughly 2 mg per 1 mL.

Control result Precisely measure 1 mL of the sample result and transfer it to a 100 mL volumetric beaker, adulterate with acetonitrile to the mark, and mix well.

Chromatographic conditions Use octadecylsilane clicked silica gel as the stationary phase, acetonitrile- water( 6040) as mobile phase A, and acetonitrile as mobile phaseB. Perform a direct grade elution according to the program in the table, acclimate the inflow rate to make the retention time of estradiol benzoate peak around 26 twinkles, descry at a wavelength of 230 nm, and fit a volume of 10 μL.

System felicity conditions The theoretical plate number calculated grounded on the peak of Estradiol Benzoate Powder shouldn't be lower than 4500, and the separation between the estradiol benzoate peak and conterminous contamination peaks should meet the conditions.

Analytical system Precisely fit the sample result and control result into the liquid chromatograph and record the chromatogram.

Limit If there are contamination peaks in the chromatogram of the sample result, the area of a single contamination peak shouldn't exceed the area of the main peak in the control result(1.0), and the sum of the areas of all contamination peaks shouldn't exceed1.5 times the area of the main peak in the control result(1.5). Chromatographic peaks with an area lower than0.01 times of the area of the main peak in the control result can be ignored.

Loss on drying:Take the sample, dry it at 105°C until constant weight, and the loss of weight should not exceed 0.5% (General Rule 0831).

Assay: Determined by high-performance liquid chromatography (General Rule 0512).

Stability and storage

The storage conditions for Benzyl estradiol are as follows:

• It should be stored in a cool, dry, and well-ventilated environment to avoid moisture, heat, and direct sunlight.

• Avoid contact with chemicals such as acids or bases to prevent chemical reactions that may render the medication ineffective.

• Keep out of reach of children and prevent accidental ingestion.

• It is recommended to store it in its original packaging to minimize exposure to air.

• If Benzyl estradiol has expired or is no longer needed, it should be properly disposed of and not casually discarded.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization:Customized logo;Customized packaging;Graphic customization

Shipping:

Lead time: Within 3 workdays after receiving payment.

Payment Term

Why Choose Xi'an Yihui?

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, as a professional Estradiol Benzoate manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

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