Diosmin Powder

CAS: 520-27-4
Latin Name: Citrus aurantium L.
Part of the Plant Used: fruit
Appearance: Grey yellow to yellow powder or crystalline powder
Standard: EP 9.0 90.0%-102.0%by HPLC
Brand: YIHUI
Packing: 25kg
Supply Ability: 5000kg per month
Shelf Life: Two years
Payment: T/T, LC or DA
Sample: available
Delivery Time: Ready Stock in Local Warehouse,1-3 days
Prompt and Secure Shipment
Origin: China
Shipping: DHL,FedEx,TNT,EMS,By Sea,By Air
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Can't sell to individuals
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Product Introduction

What is Diosmin Powder?


Diosmin Powder, a trademark flavonoid glycoside, is taken out from the citrus regular items, similar to oranges, lemons, and grapefruits. It tastes somewhat unpleasant and is a powder that is white to yellow marginally. Diosmin is dissolvable in ethanol and other natural solvents, yet not in water. Yihui's Diosmin EP is a testament to our commitment to quality and innovation. Our product undergoes a meticulous extraction process to ensure maximum purity and efficacy.

It has been used for a very long time in traditional medicine to treat a variety of conditions, including varicose veins, hemorrhoids, and other venous issues. It is moreover used to treat lymphedema, a condition that causes extending in the arms and legs.

Specification:

ITEM

SPECIFICATIONS  

RESULTS

Appearance

Solubility:

Identification[a,b]  

Residual   solvent

-            methanol

-            ethanol

-            pyridine

Iodine  

Related   substances(impurity by HPLC )

Impurity   A: acetoisovanillone

Impurity   B: hesperidin

Impurity   C: isorhoifin

Impurity   E: linarin

Impurity   F: diosmitin

Others   impuritys

Total   others impuritys and impurity A

Total   impuritys

Sulphated   ash

Water  

Assay

Particle size  

Heavy metals

Grayish-yellow   or light yellow hygroscopic powder

Practically   insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in   alcohol, It dissolves in dilute solutions of alkali hydroxides

Must positive


NMT3000ppm  

NMT5000ppm  

NMT200ppm  

≤1.0%  


≤0.5%  

≤4.0%  

≤3.0%

≤3.0%  

≤3.0%  

≤1.0%  

≤1.0%  

≤10.0%  

≤0.2%

≤6.0%  

90%--102%

≥95% pass through 80mesh

≤   10ppm

Complies


Complies


Positive


<150ppm

<250ppm

<200ppm

<0.1%


0.05%  

0.89%  

1.81%  

2.00%  

0.43%  

<1.0%

0.62%  

5.62%  

0.10%

4.01%

91.56%

Complies

<10ppm

Microbilogical  

Total Plate   Count

Yeasts and Molds  

E.Coliform

Salmonella

Coliforms


≤ 1000cfu/g

≤ 100cfu/g

Negative

Negative

≤10cfu/g


100cfu/g

20cfu/g

Negative

Negative

<10cfu/g

ArsenicMercuryCadmium   Lead   about Hesperidin (the staring material of Diosmin) is below

Arsenic

Mercury

Cadmium

Lead

NMT1ppm  

NMT0.1ppm  

NMT1ppm  

NMT3ppm  

< 1ppm  

< 0.1ppm  

< 1ppm  

< 3ppm

GMO/BSE Status: Not genetically modified organism. Free of BSE

Storage: In an airtight   container

Conclusion: The test results conform To   EP

Chemical Composition:

It is composed of diosmetin and hesperetin in precise proportions, ensuring a potent and consistent formulation.

CompoundComposition (%)
Diosmetin90
Hesperetin10

Effects and Functions :

Diosmin Powder has garnered attention for its diverse health benefits. Primarily known for its potent antioxidant properties, it neutralizes free radicals, safeguarding cells from oxidative stress. Additionally, It has anti-inflammatory effects, contributing to the alleviation of various inflammatory conditions.

  • Improves blood flow: It can assist with further developing blood stream and decrease expanding in the veins. Varicose veins and hemorrhoids may also be less likely to occur if the walls of blood vessels are strengthened.

  • Diminishes aggravation: It is a powerful calming specialist. It can assist with decreasing irritation in the body, which can further develop side effects of conditions like joint pain, asthma, and fiery gut illness.

  • Safeguards against cell harm:It is a strong cell reinforcement. It can assist with shielding cells from harm brought about by free extremists, which can prompt malignant growth and different infections.

  • Supports the safe framework: It can assist with helping the safe framework and safeguard against disease. It can also help lower the risk of getting the flu and cold.

Its most celebrated function lies in vascular health. Diosmin supports the circulatory system by promoting blood vessel tone and elasticity, reducing the risk of venous insufficiency. Moreover, it aids in mitigating symptoms associated with hemorrhoids and chronic venous disorders.

Beyond vascular health, Diosmin Powder exhibits potential in managing diabetes, as it may improve insulin sensitivity. Its immune-modulating properties further enhance its significance in overall health and well-being.

Synthesis Process:

Citrus fruits like oranges, lemons, and grapefruits contain diosmin, a natural flavonoid glycoside. It can likewise be blended in the lab from hesperidin, one more flavonoid glycoside found in citrus natural products.

The blend of Diosmin Extract from hesperidin is a multi-step process that includes the accompanying advances:

  • Hydrolysis of hesperidin: Hesperidin is first hydrolyzed to create hesperetin and rutinose. This should be possible utilizing a compound called hesperidinase or by warming hesperidin within the sight of a corrosive.

  • Methylation of hesperetin: Hesperetin methyl ether is produced after hesperetin is methylated. This should be possible utilizing a methylating specialist, for example, dimethyl sulfate or methyl iodide.

  • The hesperetin methyl ether glycosylation process: Hesperetin methyl ether is then glycosylated with rutinose to create diosmin. This should be possible utilizing a compound called diosmin synthase or by warming hesperetin methyl ether and rutinose within the sight of a corrosive.

Researchers are working to develop new methods for it that are more efficient and cost-effective. One promising approach is to use enzymes to catalyze the reactions involved in the synthesis of diosmin. Enzymes are more specific and efficient than chemical catalysts, and they can operate under milder reaction conditions.

Another approach is to use alternative starting materials for the synthesis of it. 

These new methods for synthesizing diosmin have the potential to make diosmin more affordable and accessible for use in a variety of applications.

Quality Standards :

Diosmin Powder is a natural flavonoid glycoside that is found in citrus fruits, such as oranges, lemons, and grapefruits. It is used as a dietary supplement and as an ingredient in pharmaceutical and cosmetic products.

The Powder quality standards are important to ensure that the product is safe and effective for use. These standards typically include specifications for the following:

  • Appearance: It should be a white to slightly yellow powder.

  • Odor: It should have a slight citrus odor.

  • Taste: It should have a slightly bitter taste.

  • Solubility: It should be insoluble in water but soluble in ethanol and other organic solvents.

  • Purity: It should have a purity of at least 98%.

  • Identity: It should be identified by its characteristic spectroscopic properties.

  • Heavy metals: It should contain no more than 10 ppm of heavy metals, such as lead, mercury, and arsenic.

  • Pesticides: It should contain no more than 0.1 ppm of pesticides.

  • Microbiological contamination: It should be free of microbiological contamination, such as bacteria, yeast, and mold.

It quality standards may vary depending on the intended use of the product. For example, diosmin that is used in pharmaceutical products may have stricter quality standards than diosmin that is used in dietary supplements.

Application Fields in Various Industries :

Diosmin Powder finds versatile applications across various industries. In the pharmaceutical sector, it is a key ingredient in medications targeting vascular and inflammatory conditions. The cosmetic industry harnesses its antioxidant properties in skincare formulations. Moreover, the food and beverage industry incorporates it into functional foods and beverages, promoting cardiovascular health.

  • It is likewise utilized in a mix with different medications to treat conditions like lymphedema and diabetic retinopathy.

  • It is a component of dietary supplements that are used to treat and prevent a variety of health conditions, such as hemorrhoids, varicose veins, spider veins, and chronic venous insufficiency.

  • It is additionally utilized in dietary enhancements for its cell reinforcement and calming properties.

  • It is utilized as a fixing in skin health management items, like creams, salves, and serums, for its cell reinforcement and calming properties.

  • It is likewise utilized in hair care items, like shampoos and conditioners, for its capacity to further develop hair strength and sparkle.

  • It is utilized in some creature feed items to work on creature wellbeing and execution.

  • It is likewise utilized in a few modern applications, like the development of colors and shades.

Diosmin power is a flexible compound with a large number of likely applications across different businesses. Its medical advantages, normal beginning, and moderately minimal expense make it an appealing element for different items.

OEM Services:

Yihui proudly offers OEM services, providing clients with the flexibility to customize Diosmin Powder formulations according to their specific requirements. Our experienced team ensures seamless integration of personalized solutions, maintaining the integrity and quality of the final product.

Contact Us:

Yihui's commitment to quality, adherence to international standards, and the array of certifications (ISO, Kosher, Halal, and GMP) make us a trusted partner in the Diosmin Powder market. For inquiries and orders, contact us at sales@yihuipharm.com.

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If you have any enquiry about quotation or cooperation, please feel free to email us at E-mailor use the following enquiry form. Our sales representative will contact you within 24 hours.Thank you for your interest in our products.

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