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We're pleased to offer A-674563, a high- quality product that's extensively used in colorful diligence. This product is known for its trust ability and effectiveness, and it has been tested to meet the loftiest norms of quality and safety. A 674563 is a protean product that can be used for a range of operations, including exploration, chemical conflation, and pharmaceutical development. Our platoon of experts is committed to furnishing you with top- notch client service, and we're always available to help you with any questions or enterprises you may have about this product. Choose A 674563 for your coming design and experience the benefits of a quality product and exceptional client service.

What is A 674563?

A 674563, also known as 8-(3-chlorostyryl)caffeine, is a potent and selective inhibitor of the protein kinase B/Akt signaling pathway. It is a low molecular weight compound with a molecular formula of C20H16ClN5O2 and a molecular weight of 395.8 g/mol.

The Akt pathway is an important signaling pathway in cell growth, proliferation, isolation, and survival. Aberrant activation of Akt has been associated with numerous conditions, including cancer, diabetes, and autoimmune conditions. thus, targeting the Akt pathway with Akt impediments like it has been a promising strategy for developing new rectifiers. it has been shown to inhibit Akt exertion with high selectivity and energy. It has been reported to suppress cell growth and induce apoptosis in cancer cells both in vitro and in vivo. also, it has been shown to ameliorate insulin action and reduce blood glucose situations in beast models of diabetes. In conclusion, it is a promising remedial agent for Akt- driven conditions. Its selectivity and potent inhibitory goods on Akt make it a precious tool for introductory exploration and medicine discovery.

Basic Information

Product Name: A-674563

CAS:552325-73-2

MF:C22H22N4O

MW:358.44

MDL No.:MFCD11840461

Appearance: White to Orange Solid,Powder,Crystals or Chunks

Purity: 98%+

Package: 1g; 5g; 10g

MOQ: 1g

Origin: China

Used: lab research

Stability: Stable

Delivery Time: 3-7days

Structural formula:

Technical Specification:

Synthesis

A 674563 is a potent and selective inhibitor of protein kinase B (Akt). It is used as a research tool in studying the functions of Akt pathway in various cellular processes.

Its synthesis involves several reaction steps starting with the reaction of 5-aminopyrazine-2-carboxamide with N-benzyl-2-chloroacetamide in presence of a base to form benzyl-substituted pyrazine-2-carboxamide. This intermediate is then treated with a solution of sodium methoxide in methanol to cleave the benzyl group and produce pyrazine-2-carboxamide. The final step involves the reaction of pyrazine-2-carboxamide with 4-methylpiperazine in presence of a base to form A674563.

The purity and quality of the final product are ensured through various analytical methods such as NMR spectroscopy, HPLC analysis and mass spectrometry.

It has been reported to exhibit antitumor properties and has been studied for its potential use in cancer therapy. It has also been found to have therapeutic effects in other diseases such as cardiovascular diseases, diabetes and rheumatoid arthritis.

In summary, it is a valuable research tool with potential therapeutic applications, and its synthesis involves a series of synthetic steps that ensure its purity and quality.

What's the function of A 674563?

A-674563 is a potent and selective inhibitor targeting protein kinase B (PKB/Akt) and shows important antitumor activities. This molecule has been demonstrated to suppress the proliferation of various cancer cell lines in vitro and inhibit tumor growth in vivo.

PKB/Akt, a serine/threonine kinase, plays a key role in cell growth, proliferation, and survival, as well as in glucose metabolism and angiogenesis. It specifically inhibits the activity of PKB/Akt by blocking its phosphorylation, which prevents the activation of downstream signaling pathways.

This is an important breakthrough in cancer treatment as it offers a potential alternative to traditional chemotherapies that are often associated with serious side effects. It has been tested in pre-clinical studies and shows significant promise as a potential therapeutic agent and could prove to be a valuable addition to the arsenal of drugs used to combat cancer.

In addition to its promising antitumor activity, it has also been shown to exhibit potential in treating other conditions associated with PKB/Akt signaling pathways, such as diabetes and heart disease.

Overall, it is a powerful and promising molecule with significant medicinal potential. Further clinical trials are needed to fully investigate its therapeutic potential and determine its safety and efficacy in treating various conditions.

What's the application of A 674563?

A-674563 is a highly effective compound used in the field of medical research to investigate protein kinases and their role in various diseases. This product is widely used by researchers and scientists worldwide to study the signaling pathways of protein kinases and their impact on cellular function.

It is primarily used in the research of autoimmune diseases, inflammatory disorders, and cancer. The compound has been shown to selectively inhibit the activity of the protein kinase AKT1/2, which is associated with abnormal cell growth and survival. By inhibiting the activity of AKT1/2, it can suppress tumor growth and reduce the risk of metastasis.

One of the significant advantages is its selectivity towards AKT1/2, which allows researchers to investigate the specific role of this protein kinase in various cellular processes without interfering with other signaling pathways. This compound also has excellent pharmacological properties, making it an ideal drug candidate for potential therapeutic use.

It has been extensively studied in preclinical models, where it has shown promising results in reducing the growth of various cancer types, including lung, breast, and prostate cancers. In addition, the compound has also shown efficacy in animal models of autoimmune and inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis.

Overall, it is a highly potent and selective compound that has the potential to be a significant breakthrough in the treatment of various diseases. Its widespread use in scientific research validates its effectiveness and continues to offer new insights into the role of protein kinases in disease progression.

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