6-Aminocaproic Acid
CAS No.: 60-32-2
MOQ: 1kg
Assay: 99%
Packing: 1kg/bag;25kg/drum
Supply Ability: 10000kg per month
Used: medicine grade; industrial grade
Delivery Time:in stock
Shelf Life: Two years
Payment: T/T, LC or DA
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Product Introduction
What is 6-Aminocaproic acid?
6-Aminocaproic acid, also known as Aminohexanoic acid, ε- aminocaproic acid, or tranexamic acid, has the chemical formula H2NCH2( CH2) 3CH2COOH. It has a CAS number of 60-32-2 and a molecular weight of131.18. It has a harsh flavor and is odorless, coming from ether as lush chargers. It melts at a temperature between 202- 207 °C( corruption). undoable in ethanol, ether, and chloroform, it's answerable in water and just hardly answerable in methanol. Its pK2 is10.75, while its pK1 is4.43. The alkaline KMnO4 result has the capability to oxidize it into adipic acid. When replied with HNO2, it forms 5- hexenoic acid and 4- hexenoic acid. It's converted to 6-ureidohexanoic acid by boiling it with urea and barium hydroxide result. Esters can be created when it reacts with alcohols( ROH), and acylating agents( RCOCl) can introduce acyl groups on the aminogroup.It can be made in two ways by hydrolyzing 6-( N- benzoylamino) hexanenitrile in the presence of hydrochloric acid, or by hydrolyzing caprolactam in the presence of hydrochloric acid and also treating the product with ammonium hydroxide.It serves as an antifibrinolytic agent and is employed in chemical conflation.
As a hemostatic agent, 6-Aminocaproic acid's used to treat severe bleeding brought on by elevated fibrinolysis and is relatively effective in doing so. During numerous procedures, it's suitable for oozing or original bleeding. also, it's employed in gynecology and obstetrics for hemoptysis, gastrointestinal bleeding, and bleeding disorders.A typical antifibrinolytic hemostatic drug is 6-aminohexanoic acid, frequently known as aminocaproic acid or epsilon- aminocaproic acid. By competitively blocking the activation of plasminogen activators and precluding the conversion of plasminogen to plasmin, it exerts antifibrinolytic conduct. It also slows the breakdown of fibrin into peptides and amino acids by having a weak direct inhibitory effect on plasmin. Blood must have a 6-aminohexanoic acid attention of 130 mg/ L or advanced to help plasminogen from turning into plasmin, and blood must have a attention of 1300 mg/ L or advanced to help plasmin from acting directly, which prevents fibrin from dissolving and results in hemostasis.
Its activity lasts quite briefly and has a mild, quick-elimination impact.With an 80% bioavailability after oral administration, it is quickly and thoroughly absorbed in the digestive system. After consumption, peak blood concentrations are obtained in under two hours. Its half-life is approximately 103 minutes, and the majority of it is eliminated intact in the urine.
Basic Information
Product name: 6-Aminohexanoic acid
CAS:60-32-2
MF: C6H13NO2
MW:131.17
EINECS:200-469-3
MDL No.:MFCD00008238
Storage Temperature: Store below +30°C.
Stability: Stable
Structural formula:
Quality standard
Item | Specification | Results |
Character | White crystalline powder. | White crystalline powder. |
Freely soluble in water, almost insoluble in ethanol and and chloroform or ether. | Conforms | |
Melting point | 204～207C | 204.0～~204.5℃ |
Identification | The Infrared absorption spectrum is concordant with the reference spectrum. | Conforms |
Clarity of solution | Should be conform | Conforms |
pH | 7.5~8.0 | 7.9 |
Sulfate | NMT 0.01% | Conforms |
Calciumion | Should be conform | Conforms |
Chloride | NMT 14ppm | Conforms |
Loss on drying | NMT 0.5% | 0.06% |
Water by KF | NMT 0.5% | 0.1% |
Residue on ignition | NMT 0.1% | 0.03% |
Heavy metals | NMT 10ppm | Conforms |
Arsenic salt | NMT 2ppm | Conforms |
Bacterial endotoxin | <0.5EU/mg | Conforms |
Microbial limit | Total aerobic bacteria:≤1000cfu/g | <10cfu/g |
Molds and yeasts:≤100cfu/g | <10cfu/g | |
Escherichia coli: Negative | Negative | |
Absorbance | 287nm, no more than 0.10 450nm, no more than 0.03 | 287nm, 0.041 450nm, 0.007 |
287nm, no more than 0.15 450nm, no more than 0.03 | 287nm, 0.125 450nm, 0.011 | |
Assay | ≥98.5% on drying basis | 99.4% |
Function and application
It serves a variety of purposes and has the following applications:
Hemostatic agent An important hemostatic medicine, It prevents fibrinolysis, slows down the breakdown of fibrinogen, and increases the stability of blood clots. It's used to treat a variety of bleeding conditions, similar as upper gastrointestinal bleeding, surgical bleeding, traumatic bleeding, and gynecological bleeding.
Antifibrinolytic agent Aminocaproic acid is an antifibrinolytic medicine that can reduce fibrinogen declination by blocking the conversion of plasminogen to plasmin. This quality makes it useful for treating bleeding brought on by hyperfibrinolysis.
Antifibrinolytics agentIncreased fibrinogen dissolving exertion may do in some conditions or following surgery, exacerbating the liability to hemorrhage. It can be used as an antifibrinolytic to help fibrinogen from breaking down and to manage bleeding.
Effect on inflammation According to certain exploration, It has the capability to suppress seditious responses and the release of seditious intercessors. It demonstrates pledge in the operation of several seditious ails.
Antitumor effect: Aminocaproic acid may have inhibitory effects on tumor growth and metastasis, exhibiting specific anticancer effectiveness against specific forms of cancer, according to some research. Further research is necessary to determine the particular anticancer mechanism, though.
A versatile substance with significant uses in hemostasis, antifibrinolysis, anti-inflammation, and perhaps anticancer actions, It is summarized above. However, particular dosages and usage strategies should be decided upon taking into account each patient's unique situation and expert medical assistance. Prior to use, please speak with a physician or pharmacist.
Stability & storage
When kept under the right conditions, aminocaproic acid, also known as 6-aminohexanoic acid, is often stable. The stability and storage recommendations for 6-aminohexanoic acid are as follows:
Temperature: 6-Aminohexanoic acid should be kept between 20°C and 25°C (68°F and 77°F) at room temperature.
Moisture: Prevent excessive moisture from damaging the substance. It is better to keep it in a container that is completely sealed.
Light: Avoid exposing 6-aminohexanoic acid for an extended period of time to intense light sources or direct sunlight. Keep it in a container that is dark or opaque.
Incompatible substances: contrasting substances To prevent deterioration, keep 6-aminohexanoic acid away from or incompatible materials such oxidizing agents, potent acids, or bases.
package: To preserve its stability, 6-aminohexanoic acid should be kept in its original package or a tightly sealed container.
Packing & Shipping
Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.
Customization: Customized logo; Customized packaging; Graphic customization
Shipping:
Item | Quantity | ETA time | Shipping Method |
By Courier | ≤50kg | 7-15days | Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient |
By Air | 50kg~200kg | 3-5days | Fast and cheap |
By Sea | Large quantity | 20-35days | Cheapest way |
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In conclusion
In summary, as a professional 6-Aminocaproic acid manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make our Aminohexanoic acid stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.
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