Azacytidine

We supply 5- Azacytidine API

We're proud to offer 5- Azacytidine API, a high- quality medicinal component used as an antineoplastic and antiviral agent. This API is primarily used in the treatment of acute myeloid leukemia, myelodysplastic pattern, and habitual myelomonocytic leukemia. Our product is manufactured in compliance with strict quality norms, icing its chastity and effectiveness. It's available in colorful packaging sizes to suit your specific conditions. Trust us to give you with a dependable and effective force of 5- Azacytidine. communicate us moment to learn further about this product and how we can help you.

What is Azacytidine?

5- Azacytidine powder, also known as Azacitidine or 5- AC, is a chemical substance. It's a nucleoside analog made of an adenine base and a ring-shaped patch nominated a nitrogen heterocycle that contains nitrogen. It's a DNA methyltransferase asset and is constantly used to treat myelodysplastic pattern( MDS), a blood condition.Its chemical name is 4- Amino- 1-(- D- ribofuranosyl)( 1H)- one, and its CAS number is 320-67-2. Its chemical formula is C8H12N4O5, and its molecular weight is 244.2 g/ spook. It can alter gene expression and have remedial benefits in conditions like myelodysplastic pattern( MDS) by snooping with the DNA methylation process. By precluding DNA methylation changes, it promotes the growth of healthy hematopoietic cells and reverses the conformation of imperfect hematopoietic cells.

The discovery of 5-Azacytidine's discovery dates back to the 1950s. An overview of its findings can be found here:

The first Azacytidine API conflation was carried out in 1958 by experimenters from the Chemical Development Section of the National Institutes of Health in the United States. They set up that this substance inhibited the methylation of cellular DNA.

The National Cancer Institute( NCI) in the United States started conducting fresh exploration on azacytidine in 1964.

Azacitidine powder passed fresh exploration and development throughout the preceding decades. The U.S. Food and Drug Administration( FDA) granted Azacytidine( also retailed as Vidaza) blessing in 1985 for the operation of high-threat myelodysplastic pattern( MDS). As a result, it has been constantly employed to treat MDS also.

Basic Information

Product Name: 5-Azacytidine
CAS:320-67-2
MF:C8H12N4O5
MW:244.2
EINECS:206-280-2
MDL No.:MFCD00006539
Purity:99%
Stability: Stable for 2 years
solubility: Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
Application: Medicine grade or used for research.
Packing: As per your request
Storage: Room temp.
Structural formula:

Melting point: 226 to 232 ℃

Boiling point: 534.5 ℃

Water solubility: soluble

Density: 2.08 g/cm ³

Flash point: 277 ℃

Quality standard

Packing:  500g/bag;1kg/bag

Storage conditions: -20 ℃, moisture-proof, sealed, and light proof

Transportation conditions: 2-8 ℃ transportation

Category: Toxic substances

Toxicity classification: highly toxic

Acute toxicity: Oral LD50 in mice: 572 mg/kg; Abdominal cavity mouse LD50: 68 mg/kg

Flammability hazard characteristics: flammable; Burning produces toxic nitrogen oxide smoke; Side effects of medication for patients: nausea, vomiting, diarrhea, and decreased white blood cells

Extinguishing agent: dry powder, foam, sand, carbon dioxide, atomized water

What is the application of 5-Azacytidine powder ?

The following are the main uses for 5-Azacytidine powder and its application areas:

1.Antimetabolic drugs

The main indication is acute myeloid leukemia that is ineffective against conventional treatment. It is also used for breast cancer, melanoma, intestinal cancer, etc. The main manifestations of toxicity are leukopenia, thrombocytopenia, and anemia. Nausea and vomiting are common adverse reactions, which can be improved by prolonged infusion or by using antiemetics 24 to 48 hours before treatment. Other toxic effects include diarrhea, neuromuscular disorders, fever, hypotension, and rash. The formulation is freshly prepared 3-4 hours before use.

2.A potent growth inhibitor and cytotoxic agent

Inhibition of DNChemicalbookA methyltransferase, an important regulatory mechanism for gene expression, activation, and silencing; Cancer suppressants with weak antibody activity (Gram positive); Used to study the effect of DNA merging molecules during DNA methylation process

3. A potential growth inhibitory factor and cytotoxic carrier

Inhibiting DNA methyltransferase, which is an important regulatory mechanism for gene expression, gene activation, and gene shutdown. This factor causes DNA demethylation or semi demethylation, allowing transcription factors to bind to DNA and reactivate tumor suppressor genes.

Security information

Dangerous goods label: T

Hazard category code: 45-46-22

Safety instructions: 53-22-36/37/39-45

WGK Germany: 3

RTECS number: XZ3017500

F: 10-23

Customs code: 29349990

Toxic Substances Data: 320-67-2

Toxicity: LD50 in mice (mg/kg): 115.9 i.p; 572.3 Orally (Palm, Kensler)

Pharmacological action

Azacytidine exerts its anti-tumor effect by reducing DNA methylation and exerting direct cytotoxicity on bone marrow abnormal hematopoietic cells. In vitro studies have shown that the concentration of this product at maximum inhibition of DNA methylation does not significantly hinder DNA synthesis. The phenomenon of low methylation can restore the normal function of genes closely related to the differentiation and proliferation of fine chemical books. The cytotoxic effect of this product can cause the death of rapidly proliferating cells, including cancer cells that have lost normal mechanism control, while non proliferating cells are relatively insensitive to this product. Overview, physicochemical properties, preparation methods, pharmacological effects, and applications of azacitidine

Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In summary, as a professional Azacitidine API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support.

our contact information: 

E-mail:sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937

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